Ovarian cancer is a disease in which malignant cells form in the tissues of the ovaries. It is the fifth leading cause of cancer death in women. Several factors can increase the risk of developing ovarian cancer, including family history, age, and use of hormone replacement therapy (HRT).
Some forms of HRT may help reduce the risk of ovarian cancer. The key is the type of HRT used:
- Estrogen-only HRT has been associated with an increased risk of ovarian cancer
- HRT with estrogen plus progestin may help lower ovarian cancer risk
Specifically, research indicates that using estrogen along with
progestin for at least 5 years can reduce ovarian cancer risk. Some key study findings:
- A 2020 study found that estrogen-progestin therapy for 5 years was associated with a 23-27% lower ovarian cancer risk compared to never using hormones
- A 2010 analysis of multiple studies found that estrogen plus progestin HRT for 3-6 years reduced ovarian cancer risk by 29%
The protective effect appears strongest with longer-term consistent use.
Exactly why progestins may lower risk is still being studied, but possible reasons include:
- Progestins help counteract the potentially harmful ovarian cell growth effects of estrogen
- Progestins may help trigger programmed cell death (apoptosis) in abnormal ovarian cells
More research is still needed, but the current evidence suggests
progestin-combination HRT lasting at least 3-5 years may offer protective benefits against ovarian cancer.
When considering HRT for ovarian cancer risk reduction, Balance and
moderation are key principles:
- HRT doses should not exceed the minimal effective levels needed to relieve menopause symptoms
- The increased risk of health issues like stroke and blood clots should be weighed against potential benefits
- Close monitoring and reassessment of continuing HRT every 1-2 years is wise
If you're approaching menopause or experiencing symptoms, have an open discussion with your doctor about your health history and options for relief - including specifics about HRT regimens that may reduce ovarian cancer risk.
At
Renew Medical HRT Clinic, we specialize in personalized
hormone replacement therapies and balancing treatments tailored to your unique needs and health goals:
- Our compassionate doctors and nurses take the time to listen and understand your situation
- We stay up-to-date on the latest medical research to craft integrative plans
- We offer customizable bioidentical HRT, nutrition plans, stress reduction techniques
- We conduct regular follow-ups to ensure your treatments are working and adjust as needed
Managing menopause symptoms while reducing health risks is possible.
Contact Renew Medical HRT Clinic today to learn about science-based hormone therapy approaches that may help lower your chances of ovarian cancer. Our expertise and care can help guide you to better wellbeing during this transition.
